Bovine WASHC1/ WASH complex subunit 1 CLIA Kit

货号:

商标:

EIAab^®

监管等级:

RUO

别名:

WAS protein family homolog 1, WASH1

检测方法:

CLIA

特异性:

Natural and recombinant bovine WASH complex subunit 1

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

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Bovine WASHC1 CLIA Kit

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通用注释

亚单元:

Component of the WASH core complex also described as WASH regulatory complex SHRC composed of WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. The WASH core complex associates with the F-actin-capping protein dimer (formed by CAPZA1, CAPZA2 or CAPZA3 and CAPZB); the assembly has been initially described as WASH complex (PubMed:20498093). Interacts (via WHD1 region) with WASHC2; the interaction is direct. Interacts with alpha-tubulin. Interacts with BECN1; WASHC1 and AMBRA1 can competetively interact with BECN1. Interacts with BLOC1S2; may associate with the BLOC-1 complex. Interacts with tubulin gamma chain (TUBG1 or TUBG2).

功能:

Acts as a nucleation-promoting factor (NPF) at the surface of endosomes, where it recruits and activates the Arp2/3 complex to induce actin polymerization, playing a key role in the fission of tubules that serve as transport intermediates during endosome sorting. Its assembly in the WASH core complex seems to inhibit its NPF activity and via WASHC2 is required for its membrane targeting. Involved in endocytic trafficking of EGF. Involved in transferrin receptor recycling. Regulates the trafficking of endosomal alpha5beta1 integrin to the plasma membrane and involved in invasive cell migration. In T-cells involved in endosome-to-membrane recycling of receptors including T-cell receptor (TCR), CD28 and ITGAL; proposed to be implicated in T-cell proliferation and effector function. In dendritic cells involved in endosome-to-membrane recycling of major histocompatibility complex (MHC) class II probably involving retromer and subsequently allowing antigen sampling, loading and presentation during T-cell activation. Involved in negative regulation of autophagy independently from its role in endosomal sorting by inhibiting BECN1 ubiquitination to inactivate PIK3C3/Vps34 activity.

亚细胞位置:

Early endosome membrane Recycling endosome membrane Late endosome Cytoplasmic vesicle Autophagosome Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Centriole Localization to the endosome membrane is mediated via its interaction with WASHC2.

数据库链接

UniGene:

Bt.35980

STRING:

9913.ENSBTAP00000015790

KEGG:

bta:533602

Pfam:

PF11945

Uniprot:

A7Z063

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