WDR18 (基因名), WD repeat-containing protein 18 (蛋白名), wdr18_bovin.
通用注释
亚单元:
Component of the 5FMC complex, at least composed of PELP1, LAS1L, TEX10, WDR18 and SENP3; the complex interacts with methylated CHTOP and ZNF148. Interacts with NOL9.
功能:
May play a role during development. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
亚细胞位置:
Nucleus
Nucleoplasm
Cytoplasm
Mainly found in the nucleoplasm, with low levels detected in the cytoplasmic and chromatin fractions.
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