Human WDR83/ WD repeat domain-containing protein 83 CLIA Kit

货号:

U7904h

商标:

EIAab^®

监管等级:

RUO

别名:

Mitogen-activated protein kinase organizer 1, MAPK organizer 1, MORG1

检测方法:

CLIA

特异性:

Natural and recombinant human WD repeat domain-containing protein 83

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human WDR83 CLIA Kit

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通用注释

亚单元:

Interacts with EGLN3/PHD3. Interacts with ERK signaling proteins MAP2K1/MEK1, MAP2K2/MEK2, LAMTOR3, ARAF/Raf-1, MAPK1/ERK2 and MAPK3/ERK1 (By similarity). Identified in the spliceosome C complex.

功能:

Molecular scaffold protein for various multimeric protein complexes. Acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. Also involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). May also be involved in pre-mRNA splicing.

亚细胞位置:

Cytoplasm Nucleus Predominantly cytoplasmic. Partially nuclear.

数据库链接

UniGene:

Hs.657204

SMR:

Q9BRX9

STRING:

9606.ENSP00000242796

KEGG:

hsa:84292

Pfam: