Human WEE1/ Wee1-like protein kinase CLIA Kit

货号:

U5411h

商标:

EIAab^®

监管等级:

RUO

别名:

Wee1A kinase, WEE1hu

检测方法:

CLIA

特异性:

Natural and recombinant human Wee1-like protein kinase

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human WEE1 CLIA Kit

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产品说明书

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通用注释

亚单元:

N/A

功能:

Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.

亚细胞位置:

Nucleus

数据库链接

UniGene:

Hs.249441

SMR:

P30291

STRING:

9606.ENSP00000402084

KEGG:

hsa:7465

MIM: