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Wipi2 (基因名), WD repeat domain phosphoinositide-interacting protein 2 (蛋白名), wipi2_rat.

产品名称:

Rat Wipi2/ WD repeat domain phosphoinositide-interacting protein 2 CLIA Kit

货号:

U15998r

商标:

EIAab^®

监管等级:

RUO

别名:

WIPI-2

检测方法:

CLIA

特异性:

Natural and recombinant rat WD repeat domain phosphoinositide-interacting protein 2

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

Cancer

规格 & 价格:

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Rat Wipi2 CLIA Kit

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通用注释

亚单元:

Interacts with TECPR1, ATG16L1 and ATG5.

功能:

Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). Recruits the ATG12-ATG5-ATG16L1 complex to omegasomes, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Omegasomes are derived from ER and serve as intermediates for genesis of isolation membrane (also called preautophagosome) from ER cisternae membranes.

亚细胞位置:

Preautophagosomal structure membrane Peripheral membrane protein Cytoplasmic side Localizes to omegasomes membraneswhich are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures. Enriched at preautophagosomal structure membranes in response to PtdIns3P.

数据库链接

UniGene:

Rn.163194

STRING:

10116.ENSRNOP00000001476

KEGG:

rno:288498

Uniprot:

Q6AY57

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