ZBP1 (基因名), Z-DNA-binding protein 1 (蛋白名), zbp1_human.
产品名称:
Human ZBP1/ Z-DNA-binding protein 1 CLIA Kit
货号:
U9277h
商标:
EIAab®
监管等级:
别名:
Tumor stroma and activated macrophage protein DLM-1, C20orf183, DLM1
检测方法:
CLIA
特异性:
Natural and recombinant human Z-DNA-binding protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
N/A
功能:
Participates in the detection by the host's innate immune system of DNA from viral, bacterial or even host origin. Plays a role in host defense against tumors and pathogens. Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream interferon regulatory factor (IRF) and NF-kappa B transcription factors, leading to type-I interferon production. ZBP1-induced NF-kappaB activation probably involves the recruitment of the RHIM containing kinases RIPK1 and RIPK3.
亚细胞位置:
N/A
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