Zbtb17 (基因名), Zinc finger and BTB domain-containing protein 17 (蛋白名), zbt17_mouse.
产品名称:
Mouse Zbtb17/ Zinc finger and BTB domain-containing protein 17 CLIA Kit
货号:
-
商标:
EIAab®
监管等级:
别名:
LP-1, Polyomavirus late initiator promoter-binding protein, Zinc finger protein 100, Zinc finger protein 151, Zinc finger protein Z13, Zfp-100, Zfp100, Znf151
检测方法:
CLIA
特异性:
Natural and recombinant mouse Zinc finger and BTB domain-containing protein 17
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Cancer
通用注释
亚单元:
Homooligomerizes (via the BTB/POZ domain), multimerization is required for DNA binding. Binds to the C-terminal helix-loop-helix motif of MYC which inhibits ZBTB17 transactivation and growth arrest activities and renders it insoluble in the nucleus. Also interacts with HCFC1, MAGEA4 and TMPRSS11A. Interacts (via the C-terminal zinc fingers) with GFI1; the interaction results in the recruitment of MYC to the CDKN1A/p21 and CDKN1B promoters and repression of transcription. Interacts with TRAF2, interfering with the binding of UBC13 to TRAF2, and inhibiting TRAF2 E3 ligase activity. Interacts with BCL6; the interaction inhibits ZBTB17 transactivation activity on target genes involved in cell cycle arrest. Interacts with ZBTB49; this interaction blocks ZBTB17-mediated repression of RB1.
功能:
Transcription factor that can function as an activator or repressor depending on its binding partners, and by targeting negative regulators of cell cycle progression. Has been shown to bind to the promoters of adenovirus major late protein and cyclin D1 and activate transcription. Required for early embryonic development during gastrulation. Plays a critical role in early lymphocyte development, where it is essential to prevent apoptosis in lymphoid precursors, allowing them to survive in response to IL7 and undergo proper lineage commitment. Represses RB1 transcription; this repression can be blocked by interaction with ZBTB49.
亚细胞位置:
Nucleus
数据库链接
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