ZBTB1 (基因名), Zinc finger and BTB domain-containing protein 1 (蛋白名), zbtb1_human.
产品名称:
Human ZBTB1/ Zinc finger and BTB domain-containing protein 1 CLIA Kit
货号:
-
商标:
EIAab®
监管等级:
别名:
KIAA0997
检测方法:
CLIA
特异性:
Natural and recombinant human Zinc finger and BTB domain-containing protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Homodimer. Homooligomer. Isoform 1 and isoform 2 can homodimerize. Heterodimer of isoform 1 and isoform 2. Interacts (via BTB domain) with TRIM28 (unphosphorylated or phosphorylated form) (PubMed:24657165).
功能:
Acts as a transcriptional repressor (PubMed:20797634). Represses cAMP-responsive element (CRE)-mediated transcriptional activation (PubMed:21706167). In addition, has a role in translesion DNA synthesis. Requires for UV-inducible RAD18 loading, PCNA monoubiquitination, POLH recruitment to replication factories and efficient translesion DNA synthesis (PubMed:24657165). Plays a key role in the transcriptional regulation of T lymphocyte development.
亚细胞位置:
Nucleus
Nucleus
Nucleoplasm
Localized in dot-like structures in the nucleus (PubMed:21706167). Colocalized with SMRT in nuclear bodies (PubMed:20797634). The sumoylated form is preferentially located in the nucleoplasm outside the nuclear bodies(PubMed:20797634).
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