Zc3hav1 (基因名), Zinc finger CCCH-type antiviral protein 1 (蛋白名), zcchv_mouse.
产品名称:
Mouse Zc3hav1/ Zinc finger CCCH-type antiviral protein 1 CLIA Kit
货号:
U16041m
商标:
EIAab®
监管等级:
别名:
ADP-ribosyltransferase diphtheria toxin-like 13, Inactive Poly [ADP-ribose] polymerase 13, ARTD13, PARP13
检测方法:
CLIA
特异性:
Natural and recombinant mouse Zinc finger CCCH-type antiviral protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
Epigenetics
通用注释
亚单元:
Homodimer or homooligomer. Homooligomerization is essential for its antiviral activity (By similarity). Interacts with EXOSC5 (By similarity). Interacts (via N-terminal domain) with DDX17 in an RNA-independent manner (By similarity). Interacts with EXOSC3, EXOSC7, DCP2 and DCP1A (By similarity). Interacts with PARN in an RNA-independent manner (By similarity). Interacts with XRN1 in an RNA-dependent manner (By similarity). Interacts (via N-terminal domain) with DHX30 (via N-terminus) in an RNA-independent manner (By similarity). Isoform 2 interacts (via zinc-fingers) with DDX58/RIG-I in an RNA-dependent manner (By similarity).
功能:
Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1) and moloney and murine leukemia virus (MoMLV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of DDX58/RIG-I signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).
亚细胞位置:
Cytoplasm
Nucleus
Localizes in the cytoplasm at steady state, but shuttles between nucleus and cytoplasm in a XPO1-dependent manner.
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