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ZFHX3 (基因名), Zinc finger homeobox protein 3 (蛋白名), zfhx3_human.

产品名称:

Human ZFHX3/ Zinc finger homeobox protein 3 CLIA Kit
锌指同源盒蛋白

货号:

U1065h

商标:

EIAab^®

监管等级:

RUO

别名:

AT motif-binding factor 1, AT-binding transcription factor 1, Alpha-fetoprotein enhancer-binding protein, Zinc finger homeodomain protein 3, ZFH-3, ATBF1

检测方法:

CLIA

实验类型:

Sandwich

检测范围:

10.9-700pg/mL

特异性:

Natural and recombinant human Zinc finger homeobox protein 3

样品类型:

Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids

样品数据:

研究领域:

规格 & 价格:

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Human ZFHX3 CLIA Kit

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产品说明书

说明书:

MSDS:

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数据
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通用注释

亚单元:

Interacts with FNBP3 (By similarity). Interacts with ALKBH4 and PIAS3. Interacts with ESR1. Interacts with RUNX3. Interacts with TRIM25. Interacts with SMAD2 and SMAD3.

功能:

Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3 (PubMed:25105025). Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain (By similarity). Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression (PubMed:11312261). Down-regulates the MUC5AC promoter in gastric cancer (PubMed:17330845). In association with RUNX3, upregulates CDKN1A promoter activity following TGF-beta stimulation (PubMed:20599712). Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells (PubMed:20720010).

亚细胞位置:

Nucleus Cytoplasm Translocates from the cytoplasm to the nucleus following TGF-beta stimulation. Expressed in nuclear body (NB)-like dots in the nucleus some of which overlap or closely associate with PML body.

数据库链接

UniGene:

Hs.598297

SMR:

Q15911

STRING:

9606.ENSP00000268489

KEGG:

hsa:463

MIM:

104155

Pfam:

PF00046

Uniprot:

Q15911

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Mouse Zfhx3 Protein

Mouse Zfhx3 Polyclonal Antibody

Mouse Zfhx3 Monoclonal Antibody

序列长度:

3703

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仅供参考，详细请咨询（services@eiaab.com）

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Human ZFHX3/ Zinc finger homeobox protein 3 CLIA Kit 锌指同源盒蛋白

U1065h

AT motif-binding factor 1, AT-binding transcription factor 1, Alpha-fetoprotein enhancer-binding protein, Zinc finger homeodomain protein 3, ZFH-3, ATBF1

Human ZFHX3/ Zinc finger homeobox protein 3 CLIA Kit
锌指同源盒蛋白