ZIC1 (基因名), Zinc finger protein ZIC 1 (蛋白名), zic1_human.
产品名称:
Human ZIC1/ Zinc finger protein ZIC 1 CLIA Kit
货号:
U2958h
商标:
EIAab®
监管等级:
别名:
Zinc finger protein 201, Zinc finger protein of the cerebellum 1, ZIC, ZNF201
检测方法:
CLIA
特异性:
Natural and recombinant human Zinc finger protein ZIC 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts (via the C2H2-type domains 3, 4 and 5) with MDFIC (via the C2H2-type domains 3, 4 and 5). Interacts with GLI1; the interaction enhances transcription activation. Interacts with GLI2. Interacts with GLI3; the interaction enhances transcription activation.
功能:
Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3'.
亚细胞位置:
Nucleus
Cytoplasm
Localizes in the cytoplasm in presence of MDFIC overexpression.
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