ZNF207 (基因名), BUB3-interacting and GLEBS motif-containing protein ZNF207 (蛋白名), zn207_human.
产品名称:
Human ZNF207/ BUB3-interacting and GLEBS motif-containing protein ZNF207 CLIA Kit
货号:
U5361h
商标:
EIAab®
监管等级:
别名:
Zinc finger protein 207, BuGZ, BUGZ
检测方法:
CLIA
特异性:
Natural and recombinant human BUB3-interacting and GLEBS motif-containing protein ZNF207
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Interacts (via GLEBS region) with BUB3.
功能:
Kinetochore- and microtubule-binding protein that plays a key role in spindle assembly (PubMed:24462186, PubMed:24462187, PubMed:26388440). ZNF207/BuGZ is mainly composed of disordered low-complexity regions and undergoes phase transition or coacervation to form temperature-dependent liquid droplets. Coacervation promotes microtubule bundling and concentrates tubulin, promoting microtubule polymerization and assembly of spindle and spindle matrix by concentrating its building blocks (PubMed:26388440). Also acts as a regulator of mitotic chromosome alignment by mediating the stability and kinetochore loading of BUB3 (PubMed:24462186, PubMed:24462187). Mechanisms by which BUB3 is protected are unclear: according to a first report, ZNF207/BuGZ may act by blocking ubiquitination and proteasomal degradation of BUB3 (PubMed:24462186). According to another report, the stabilization is independent of the proteasome (PubMed:24462187).
亚细胞位置:
Nucleus
Chromosome
Centromere
Kinetochore
Cytoplasm
Cytoskeleton
Spindle
Localizes primarily to the nucleus in interphase, concentrates at kinetochores prior to nuclear envelope breakdown and during early prometaphase, and disappears from kinetochores upon microtubule-binding.
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