ZNF423 (基因名), Zinc finger protein 423 (蛋白名), zn423_human.
产品名称:
Human ZNF423/ Zinc finger protein 423 CLIA Kit
货号:
U4972h
商标:
EIAab®
监管等级:
别名:
Olf1/EBF-associated zinc finger protein, Smad- and Olf-interacting zinc finger protein, hOAZ, KIAA0760, NPHP14, OAZ
检测方法:
CLIA
特异性:
Natural and recombinant human Zinc finger protein 423
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
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研究领域:
-
通用注释
亚单元:
Homodimer (By similarity). Interacts with EBF1 (By similarity). Interacts with SMAD1 and SMAD4. Interacts with PARP1. Interacts with CEP290.
功能:
Transcription factor that can both act as an activator or a repressor depending on the context. Plays a central role in BMP signaling and olfactory neurogenesis. Associates with SMADs in response to BMP2 leading to activate transcription of BMP target genes. Acts as a transcriptional repressor via its interaction with EBF1, a transcription factor involved in terminal olfactory receptor neurons differentiation; this interaction preventing EBF1 to bind DNA and activate olfactory-specific genes. Involved in olfactory neurogenesis by participating in a developmental switch that regulates the transition from differentiation to maturation in olfactory receptor neurons. Controls proliferation and differentiation of neural precursors in cerebellar vermis formation.
亚细胞位置:
Nucleus
数据库链接
验证序列:
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