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ABRAXAS1 (基因名), BRCA1-A complex subunit Abraxas 1 (蛋白名), abrx1_chick.
产品名称:

Chicken ABRAXAS1/ BRCA1-A complex subunit Abraxas 1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Coiled-coil domain-containing protein 98, Protein FAM175A, RCJMB04_33o10, ABRA1, CCDC98, FAM175A

检测方法:
ELISA
特异性:
Natural and recombinant chicken BRCA1-A complex subunit Abraxas 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Chicken ABRAXAS1 ELISA Kit
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Chicken ABRAXAS1 ELISA Kit
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通用注释


亚单元:
Component of the BRCA1-A complex. Component of the BRISC complex. Homodimer. Interacts directly (when phosphorylated at Ser-402) with BRCA1. The phosphorylated homodimer can interact directly with two BRCA1 chains, giving rise to a heterotetramer (By similarity).


功能:
Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX.


亚细胞位置:
Nucleus Localizes at sites of DNA damage at double-strand breaks (DSBs).


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