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AICDA (基因名), Single-stranded DNA cytosine deaminase (蛋白名), aicda_canlf.
产品名称:

Dog AICDA/ Single-stranded DNA cytosine deaminase ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Activation-induced cytidine deaminase, Cytidine aminohydrolase, AID, AID

检测方法:
ELISA
特异性:
Natural and recombinant dog Single-stranded DNA cytosine deaminase
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Epigenetics
Dog AICDA ELISA Kit
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Dog AICDA ELISA Kit
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通用注释


亚单元:
Interacts with CTNNBL1; the interaction is important for the immunoglobulin switch activity of AICDA. Interacts (via its NLS) with KPNA1. Interacts with PKA/PRKACA and PRKAR1A/PKR1. Interacts with SUPT6H, TRIM28 and NCL.


功能:
Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.


亚细胞位置:
Nucleus Cytoplasm Predominantly cytoplasmic but shuttles between the nucleus and the cytoplasm.


该产品尚未在任何出版物中被引用。
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