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Arhgef2 (基因名), Rho guanine nucleotide exchange factor 2 (蛋白名), arhg2_rat.
产品名称:

Rat Arhgef2/ Rho guanine nucleotide exchange factor 2 ELISA Kit

货号:

E14297r

商标:
EIAab®
监管等级:
别名:

Guanine nucleotide exchange factor H1, GEF-H1

检测方法:
ELISA
特异性:
Natural and recombinant rat Rho guanine nucleotide exchange factor 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Rat Arhgef2 ELISA Kit
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Rat Arhgef2 ELISA Kit
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产品说明书
在线询价


通用注释


亚单元:
Found in a complex composed at least of ARHGEF2, NOD2 and RIPK2. Interacts with RIPK2; the interaction mediates tyrosine phosphorylation of RIPK2 by Src kinase CSK. Interacts with RIPK1 and RIPK3. Interacts with YWHAZ/14-3-3 zeta; when phosphorylated at Ser-885. Interacts with the kinases PAK4, AURKA and MAPK1. Interacts with RHOA and RAC1. Interacts with NOD1 (By similarity). Interacts (via the N- terminal zinc finger) with CAPN6 (via domain II). Interacts with DYNLT1.


功能:
Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans; acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2.


亚细胞位置:
Cytoplasm Cytoskeleton Cytoplasm Cell junction Tight junction Golgi apparatus Cytoplasm Cytoskeleton Spindle Cytoplasmic vesicle Localizes to the tips of cortical microtubules of the mitotic spindle during cell division, and is further released upon microtubule depolymerization. Colocalized with NOD2 and RIPK2 in vesicles and with the cytoskeleton.


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