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ASNA1 (基因名), ATPase ASNA1 (蛋白名), asna_bovin.
产品名称:

Bovine ASNA1/ ATPase ASNA1 ELISA Kit

货号:

E16096b

商标:
EIAab®
监管等级:
别名:

Arsenical pump-driving ATPase, Arsenite-stimulated ATPase

检测方法:
ELISA
特异性:
Natural and recombinant bovine ATPase ASNA1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Bovine ASNA1 ELISA Kit
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Bovine ASNA1 ELISA Kit
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通用注释


亚单元:
Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.


功能:
ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.


亚细胞位置:
Cytoplasm Endoplasmic reticulum Nucleus Nucleolus


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