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BACE1 (基因名), Beta-secretase 1 (蛋白名), bace1_bovin.
产品名称:

Bovine BACE1/ Beta-secretase 1 ELISA Kit
β分泌酶1

货号:

E0718b

商标:
EIAab®
监管等级:
别名:

Beta-site amyloid precursor protein cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2, Beta-site APP cleaving enzyme 1

检测方法:
ELISA
特异性:
Natural and recombinant bovine Beta-secretase 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Neurosciences
Bovine BACE1 ELISA Kit
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Bovine BACE1 ELISA Kit
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通用注释


亚单元:
Monomer. Interacts with GGA1, GGA2 and GGA3. Interacts with RTN3 and RTN4. Interacts with SNX6 (By similarity). Interacts with PCSK9 (By similarity). Interacts with NAT8 and NAT8B.


功能:
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.


亚细胞位置:
Membrane Single-pass type I membrane protein Golgi apparatus Trans-Golgi network Endoplasmic reticulum Endosome Cell surface Cytoplasmic vesicle membrane Membrane raft Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (By similarity).


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