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Canx (基因名), Calnexin (蛋白名), calx_mouse.
产品名称:

Mouse Canx/ Calnexin ELISA Kit
Calnexin

货号:

E0280m

商标:
EIAab®
监管等级:
检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.312-20ng/mL
灵敏度:
0.171ng/mL
特异性:
Natural and recombinant mouse Calnexin
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Epigenetics
Mouse Canx ELISA Kit
规格 & 价格: cart
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Mouse Canx ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Interacts with MAPK3/ERK1 (By similarity). Interacts with KCNH2 (By similarity). Associates with ribosomes (By similarity). The palmitoylated form interacts with the ribosome-translocon complex component SSR1, promoting efficient folding of glycoproteins (By similarity). Interacts with SERPINA2P/SERPINA2 and with the S and Z variants of SERPINA1 (By similarity). Part of a complex which includes CANX, DERL1, DERL2, DDOST/OST48, RPN1, RPN2, SELENOK, STT3A, VCP AND SELENOS (By similarity). Interacts with SGIP1; involved in negative regulation of endocytosis (PubMed:21747946). Interacts with PPIB.


功能:
Calcium-binding protein that interacts with newly synthesized glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse.


亚细胞位置:
Endoplasmic reticulum membrane Single-pass type I membrane protein Endoplasmic reticulum Melanosome The palmitoylated form preferentially localizes to the perinuclear rough ER (By similarity). When bound to CD3 epsilon chains, calnexin's ER retention signal can be masked, permitting it to escape ER retention.


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