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CCL20 (基因名), C-C motif chemokine 20 (蛋白名), ccl20_bovin.
产品名称:

Bovine CCL20/ C-C motif chemokine 20 ELISA Kit
C-C模体趋化因子20

货号:

E0095b

商标:
EIAab®
监管等级:
别名:

Macrophage inflammatory protein 3 alpha, Small-inducible cytokine A20, MIP-3-alpha, MIP3A, SCYA20

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
15.6-1000pg/mL
灵敏度:
7.8pg/mL
特异性:
Natural and recombinant bovine C-C motif chemokine 20
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Immunology
Bovine CCL20 ELISA Kit
规格 & 价格: cart
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Bovine CCL20 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
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通用注释


亚单元:
N/A


功能:
Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells.


亚细胞位置:
Secreted


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