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FBXO6 (基因名), F-box only protein 6 (蛋白名), fbx6_bovin.
产品名称:

Bovine FBXO6/ F-box only protein 6 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

F-box protein that recognizes sugar chains 2, FBS2, FBX6

检测方法:
ELISA
特异性:
Natural and recombinant bovine F-box only protein 6
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Bovine FBXO6 ELISA Kit
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Bovine FBXO6 ELISA Kit
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产品说明书
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通用注释


亚单元:
Part of a SCF (SKP1-cullin-F-box) protein ligase complex. Interacts with VCP, CHEK1 and CUL1.


功能:
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication.


亚细胞位置:
Cytoplasm


该产品尚未在任何出版物中被引用。
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