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GDF6 (基因名), Growth/differentiation factor 6 (蛋白名), gdf6_bovin.
产品名称:

Bovine GDF6/ Growth/differentiation factor 6 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Bone morphogenetic protein 13, Cartilage-derived morphogenetic protein 2, BMP-13, CDMP-2, GDF-6, BMP13, CDMP2

检测方法:
ELISA
特异性:
Natural and recombinant bovine Growth/differentiation factor 6
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Bovine GDF6 ELISA Kit
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Bovine GDF6 ELISA Kit
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产品说明书
在线询价


通用注释


亚单元:
Homodimer; disulfide-linked.


功能:
Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map. Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal strucutres. Seems to positively regulates differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG. Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38.


亚细胞位置:
Secreted


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