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Gria1 (基因名), Glutamate receptor 1 (蛋白名), gria1_rat.
产品名称:

Rat Gria1/ Glutamate receptor 1 ELISA Kit
谷氨酸受体1

货号:

E11293r

商标:
EIAab®
监管等级:
别名:

AMPA-selective glutamate receptor 1, GluR-A, GluR-K1, Glutamate receptor ionotropic, AMPA 1, GluA1, GluR-1, Glur1

检测方法:
ELISA
实验类型:
Sandwich
特异性:
Natural and recombinant rat Glutamate receptor 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Neurosciences
Rat Gria1 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


精密度
批内差:已知浓度的3个样本在一个板子内重复检测20次,以评估批内精密度。
批内 CV: ≤4.0%
批间差:已知浓度的3个样本在不同的板子上重复测定5次,以评估测定批间精密度。
批间 CV: ≤5.5%
回收率
回收率:低、中和高浓度的分析物被掺入到血清或者血浆样本中,进行回收实验测定。

Sample Type

Average(%)

Recovery Range(%)

Serum

108

102-114

Plasma

110

104-116

 

 

 

 

线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

105-115%

89-100%

82-82%

113-123%

EDTA plasma(n=5)

98-109%

90-90%

110-118%

96-104%

heparin plasma(n=5)

95-104%

 

110-120%

82-90%

115-125%

 

通用注释


亚单元:
Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with DLG1 via its C-terminus. Found in a complex with GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with HIP1, RASGRF2, SYNDIG1 and LRFN1. Interacts with SNX27 (via PDZ domain); the interaction is required for recycling to the plasma membrane when endocytosed and prevent degradation in lysosomes. Interacts (via PDZ-binding motif) with SHANK3 (via PDZ domain) (PubMed:12070168, PubMed:16630835, PubMed:16793768, PubMed:17069616, PubMed:18817736, PubMed:19234459, PubMed:19265014, PubMed:20805473, PubMed:21639859, PubMed:9677374). Interacts with PRKG2 (PubMed:18031684).


功能:
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.


亚细胞位置:
Cell membrane Multi-pass membrane protein Endoplasmic reticulum membrane Multi-pass membrane protein Cell junction Synapse Postsynaptic cell membrane Multi-pass membrane protein Cell junction Synapse Postsynaptic cell membrane Postsynaptic density Cell projection Dendrite Cell projection Dendritic spine Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression.


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