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JAK2 (基因名), Tyrosine-protein kinase JAK2 (蛋白名), jak2_chick.
产品名称:

Chicken JAK2/ Tyrosine-protein kinase JAK2 ELISA Kit
酪氨酸蛋白激酶JAK2

货号:

E9140c

商标:
EIAab®
监管等级:
别名:

Janus kinase 2, JAK-2

检测方法:
ELISA
实验类型:
Sandwich
特异性:
Natural and recombinant chicken Tyrosine-protein kinase JAK2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Cancer
Chicken JAK2 ELISA Kit
规格 & 价格: cart
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Chicken JAK2 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
N/A


功能:
Non-receptor tyrosine kinase involved in various processes such as cell cycle progression, apoptosis, mitotic recombination, genetic instability and histone modifications. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors, which constitutes an initiating step in signaling for many members of the cytokine receptor superfamily. Following stimulation with erythropoietin (EPO) during erythropoiesis, it is autophosphorylated and activated, leading to its association with erythropoietin receptor (EPOR) and tyrosine phosphorylation of residues in the EPOR cytoplasmic domain. Also involved in promoting the localization of EPOR to the plasma membrane. In the nucleus, plays a key role in chromatin by specifically mediating phosphorylation of 'Tyr-41' of histone H3 (H3Y41ph), a specific tag that promotes exclusion of CBX5 (HP1 alpha) from chromatin.


亚细胞位置:
Endomembrane system Peripheral membrane protein Nucleus


该产品尚未在任何出版物中被引用。
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