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JAML (基因名), Junctional adhesion molecule-like (蛋白名), jaml_human.
产品名称:

Human JAML/ Junctional adhesion molecule-like ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Adhesion molecule interacting with CXADR antigen 1, Dendritic cell-specific protein CREA7-1, UNQ722/PRO1387, AMICA1

检测方法:
ELISA
特异性:
Natural and recombinant human Junctional adhesion molecule-like
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human JAML ELISA Kit
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Human JAML ELISA Kit
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通用注释


亚单元:
Homodimer; active form in leukocyte-endothelial cell adhesion. Interacts (homodimeric form) with CXADR. Interacts (via cytoplasmic domain) with the PI3 kinase; upon CXADR-binding. Interacts with ITGA4 and ITGB1; integrin alpha-4/beta-1 may regulate leukocyte to endothelial cells adhesion by controlling JAML homodimerization.


功能:
Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR.


亚细胞位置:
Cell membrane Single-pass type I membrane protein Cell junction Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515).


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