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Jmjd7 (基因名), Bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7 (蛋白名), jmjd7_mouse.
产品名称:

Mouse Jmjd7/ Bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

JmjC domain-containing protein 7, Jumonji domain-containing protein 7, L-lysine (3S)-hydroxylase Jmjd7

检测方法:
ELISA
特异性:
Natural and recombinant mouse Bifunctional peptidase and (3S)-lysyl hydroxylase Jmjd7
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Mouse Jmjd7 ELISA Kit
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Mouse Jmjd7 ELISA Kit
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通用注释


亚单元:
Homodimer; disulfide-linked. Interacts with DRG1 and DRG2.


功能:
Bifunctional enzyme that acts both as an endopeptidase and 2-oxoglutarate-dependent monoxygenase (PubMed:28847961) (By similarity). Endopeptidase that cleaves histones N-terminal tails at the carboxyl side of methylated arginine or lysine residues, to generate 'tailless nucleosomes', which may trigger transcription elongation (PubMed:28847961). Preferentially recognizes and cleaves monomethylated and dimethylated arginine residues of histones H2, H3 and H4. After initial cleavage, continues to digest histones tails via its aminopeptidase activity (PubMed:28847961). Additionally, may play a role in protein biosynthesis by modifying the translation machinery. Acts as Fe(2+) and 2-oxoglutarate-dependent monoxygenase, catalyzing (S)-stereospecific hydroxylation at C-3 of 'Lys-22' of DRG1 and 'Lys-21' of DRG2 translation factors (TRAFAC), promoting their interaction with ribonucleic acids (RNA) (By similarity).


亚细胞位置:
Nucleus Cytoplasm


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