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JMY (基因名), Junction-mediating and -regulatory protein (蛋白名), jmy_human.
产品名称:

Human JMY/ Junction-mediating and -regulatory protein ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
检测方法:
ELISA
特异性:
Natural and recombinant human Junction-mediating and -regulatory protein
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human JMY ELISA Kit
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Human JMY ELISA Kit
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亚单元:
Interacts with p300/EP300, the complex being recruited to activated p53/TP53. Interacts with TTC5.


功能:
Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location.


亚细胞位置:
Nucleus Cytoplasm Cytoskeleton Localizes to the nucleus in most cell types. Accumulates in nucleus under DNA damage conditions, increasing p53/TP53 transcription response and reducing its influence on cell motility (By similarity). In primary neutrophils, it colocalizes with actin filaments at the leading edge and is excluded from the nucleus. Localization correlates with motility, because it moves from the nucleus to the cytoplasmic compartment when cells are differentiated from nonmotile cells into highly motile neutrophil-like cells.


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