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KCNB2 (基因名), Potassium voltage-gated channel subfamily B member 2 (蛋白名), kcnb2_human.
产品名称:

Human KCNB2/ Potassium voltage-gated channel subfamily B member 2 ELISA Kit
钾电压阀门通道亚家族B成员2

货号:

E2325h

商标:
EIAab®
监管等级:
别名:

Voltage-gated potassium channel subunit Kv2.2

检测方法:
ELISA
实验类型:
Competitive
检测范围:
0.312-20ng/mL
灵敏度:
0.13ng/mL
特异性:
Natural and recombinant human Potassium voltage-gated channel subfamily B member 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Human KCNB2 ELISA Kit
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Human KCNB2 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


精密度
批内差:已知浓度的3个样本在一个板子内重复检测20次,以评估批内精密度。
批内 CV: ≤4.6%
批间差:已知浓度的3个样本在不同的板子上重复测定5次,以评估测定批间精密度。
批间 CV: ≤8.0%
回收率
回收率:低、中和高浓度的分析物被掺入到血清或者血浆样本中,进行回收实验测定。

Sample Type

Average(%)

Recovery Range(%)

Serum

97

91-103

Plasma

99

93-105

 

 

 

 

线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

104-115%

89-89%

100-110%

104-116%

EDTA plasma(n=5)

106-116%

82-92%

89-98%

110-119%

heparin plasma(n=5)

98-107%

 

98-109%

88-100%

104-116%

 

通用注释


亚单元:
Homotetramer or heterotetramer with KCNB1. Heterotetramer with KCNS1 and KCNS2.


功能:
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain and smooth muscle cells. Channels open or close in response to the voltage difference across the membrane, letting potassium ions pass in accordance with their electrochemical gradient. Homotetrameric channels mediate a delayed-rectifier voltage-dependent outward potassium current that display rapid activation and slow inactivation in response to membrane depolarization. Can form functional homotetrameric and heterotetrameric channels that contain variable proportions of KCNB1; channel properties depend on the type of alpha subunits that are part of the channel. Can also form functional heterotetrameric channels with other alpha subunits that are non-conducting when expressed alone, such as KCNS1 and KCNS2, creating a functionally diverse range of channel complexes. In vivo, membranes probably contain a mixture of heteromeric potassium channel complexes, making it difficult to assign currents observed in intact tissues to any particular potassium channel family member. Contributes to the delayed-rectifier voltage-gated potassium current in cortical pyramidal neurons and smooth muscle cells.


亚细胞位置:
Cell membrane Multi-pass membrane protein Perikaryon Cell projection Dendrite Localized uniformly throughout cell bodies and dendrites. Colocalizes with KCNB1 to high-density somatodendritic clusters on cortical pyramidal neurons.


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