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Klhl17 (基因名), Kelch-like protein 17 (蛋白名), klh17_rat.
产品名称:

Rat Klhl17/ Kelch-like protein 17 ELISA Kit
Kelch-like蛋白17

货号:

E1567r

商标:
EIAab®
监管等级:
别名:

Actinfilin

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
62.5-4000pg/mL
灵敏度:
31.43pg/mL
特异性:
Natural and recombinant rat Kelch-like protein 17
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Rat Klhl17 ELISA Kit
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Rat Klhl17 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Interacts with F-actin; the interaction disrupts the F-actin structures and leads to marked changes of neuronal morphology. Component of a complex, composed of PDZK1, SYNGAP1, KLHL17 and NMDA receptors. Interacts directly with PDZK1 (via PDZ1 domain); the interaction is important for integrity of actin cytoskeleton structures in neurons. Interacts with DLG4 and SYNGAP1. Interacts (via kelch repeats) with GRIK2 (via C-terminus); the interaction targets GRIK2 for degradation via ubiquitin-proteasome pathway. Interacts with GRIK1. Interacts with (via BTB domain) CUL3; the interaction regulates surface GRIK2 expression.


功能:
Substrate-recognition component of some cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function.


亚细胞位置:
Cell junction Synapse Postsynaptic cell membrane Postsynaptic density Cell junction Synapse Postsynaptic density.


该产品尚未在任何出版物中被引用。
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