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Lima1 (基因名), LIM domain and actin-binding protein 1 (蛋白名), lima1_rat.
产品名称:

Rat Lima1/ LIM domain and actin-binding protein 1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Epithelial protein lost in neoplasm, eplin

检测方法:
ELISA
特异性:
Natural and recombinant rat LIM domain and actin-binding protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Rat Lima1 ELISA Kit
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Rat Lima1 ELISA Kit
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通用注释


亚单元:
Interacts with NPC1L1; bridges NPC1L1 with MYO5B. Interacts with MYO5B; bridges MYO5B with NPC1L1 (By similarity). Interacts with PXN; this complex stabilizes actin dynamics. Interacts with F-actin and G-actin (By similarity).


功能:
Actin-binding protein involved in actin cytoskeleton regulation and dynamics. Increases the number and size of actin stress fibers and inhibits membrane ruffling. Inhibits actin filament depolymerization. Bundles actin filaments, delays filament nucleation and reduces formation of branched filaments (By similarity). Plays a role in cholesterol homeostasis. Influences plasma cholesterol levels through regulation of intestinal cholesterol absorption. May act as a scaffold protein by regulating NPC1L1 transportation, an essential protein for cholesterol absorption, to the plasma membrane by recruiting MYO5B to NPC1L1, and thus facilitates cholesterol uptake (By similarity).


亚细胞位置:
Cytoplasm Cell junction Focal adhesion Cytoplasm Cytoskeleton Cell membrane This cytoskeletal protein colocalizes with actin stress fibers and focal adhesion plaques. Expressed mainly in the brush border membrane of the small intestine and colocalizes with NPC1L1 and MYO5B (By similarity). Colocalizes with PXN at focal adhesions in mesangial cells (By similarity). Colocalizes with actin stress fibers in quiescent cells. PDGF stimulation induced disassembly of stress fibers and formation of peripheral and dorsal ruffles, where LIMA1 is relocalized (By similarity).


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