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Lin7a (基因名), Protein lin-7 homolog A (蛋白名), lin7a_rat.
产品名称:

Rat Lin7a/ Protein lin-7 homolog A ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Mammalian lin-seven protein 1, Vertebrate lin-7 homolog 1, MALS-1, Veli-1, Lin-7A, Mals1, Veli1

检测方法:
ELISA
特异性:
Natural and recombinant rat Protein lin-7 homolog A
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Rat Lin7a ELISA Kit
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Rat Lin7a ELISA Kit
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通用注释


亚单元:
Forms two exclusive ternary complexes with CASK and APBA1 or CASKIN1. Can also interact with other modular proteins containing protein-protein interaction domains like MPP5, MPP6, MPP7, DLG1, DLG2 and DLG3 through its L27 domain. Interacts with DLG4 and GRIN2B as well as CDH1 and CTNNB1, the channels KCNJ12/Kir2.2, KCNJ4/Kir2.3 and probably KCNJ2/Kir2.1 and SLC6A12/BGT-1 via its PDZ domain. The association of LIN7A with cadherin and beta-catenin is calcium-dependent, occurs at synaptic junctions and requires the actin cytoskeleton. Interacts with EGFR, ERBB2, ERBB3 and ERBB4 with both PDZ and KID domains. Associates with KIF17 via APBA1. Interacts with HTR4. Forms a tripartite complex composed of DLG1, MPP7 and LIN7 (LIN7A or LIN7C) (By similarity). Interacts with MARCH11.


功能:
Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells. Forms membrane-associated multiprotein complexes that may regulate delivery and recycling of proteins to the correct membrane domains. The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and APBA1 may have the potential to couple synaptic vesicle exocytosis to cell adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of the NMDA receptor) to neuronal postsynaptic density and may function in localizing synaptic vesicles at synapses where it is recruited by beta-catenin and cadherin. Required to localize Kir2 channels, GABA transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the basolateral membrane of epithelial cells.


亚细胞位置:
Cell membrane Peripheral membrane protein Basolateral cell membrane Peripheral membrane protein Cell junction Cell junction Synapse Postsynaptic cell membrane Postsynaptic density Peripheral membrane protein Cell junction Tight junction Cell junction Synapse Synaptosome Enriched in synaptosomes and at epithelial cell-cell junctions. Mainly basolateral in renal epithelial cells (By similarity).


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