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LOXL2 (基因名), Lysyl oxidase homolog 2 (蛋白名), loxl2_bovin.
产品名称:

Bovine LOXL2/ Lysyl oxidase homolog 2 ELISA Kit
赖氨酰氧化酶相关蛋白2

货号:

E14939b

商标:
EIAab®
监管等级:
别名:

Lysyl oxidase-like protein 2

检测方法:
ELISA
实验类型:
Sandwich
特异性:
Natural and recombinant bovine Lysyl oxidase homolog 2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Cancer
Bovine LOXL2 ELISA Kit
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Bovine LOXL2 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Component of some chromatin repressor complex. Interacts with SNAI1.


功能:
Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine). When secreted in extracellular matrix, promotes cross-linking of extracellular matrix proteins by mediating oxidative deamination of peptidyl lysine residues in precursors to fibrous collagen and elastin. Acts as a regulator of sprouting angiogenesis, probably via collagen IV scaffolding. When nuclear, acts as a transcription corepressor and specifically mediates deamination of trimethylated 'Lys-4' of histone H3 (H3K4me3), a specific tag for epigenetic transcriptional activation. Involved in epithelial to mesenchymal transition (EMT) via interaction with SNAI1 and participates in repression of E-cadherin, probably by mediating deamination of histone H3. Acts as a regulator of chondrocyte differentiation, probably by regulating expression of factors that control chondrocyte differentiation.


亚细胞位置:
Secreted Extracellular space Extracellular matrix Basement membrane Nucleus Chromosome Associated with chromatin. It is unclear how LOXL2 is nuclear: it contains a clear signal sequence and is predicted to localize in the extracellular medium. However, different reports confirmed the intracellular location and its key role in transcription regulation.


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