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Nrros (基因名), Transforming growth factor beta activator LRRC33 (蛋白名), lrc33_rat.
产品名称:

Rat Nrros/ Transforming growth factor beta activator LRRC33 ELISA Kit

货号:

E16110r

商标:
EIAab®
监管等级:
别名:

Leucine-rich repeat-containing protein 33^, Negative regulator of reactive oxygen species, Lrrc33

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.156-10ng/mL
灵敏度:
0.064ng/mL
特异性:
Natural and recombinant rat Transforming growth factor beta activator LRRC33
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Rat Nrros ELISA Kit
规格 & 价格: cart
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Rat Nrros ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Interacts (via LRR repeats) with TLR2, TLR3, TLR4, TLR9 and probably other Toll-like receptors (By similarity). Interacts with CYBB/NOX2; the interaction is direct. Interacts with TGFB1; associates via disulfide bonds with the Latency-associated peptide chain (LAP) regulatory chain of TGFB1, leading to regulate activation of TGF-beta-1 (By similarity).


功能:
Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS. Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling.


亚细胞位置:
Cell membrane Single-pass type I membrane protein Endoplasmic reticulum membrane Single-pass type I membrane protein


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