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Lrrc8a (基因名), Volume-regulated anion channel subunit LRRC8A (蛋白名), lrc8a_rat.
产品名称:

Rat Lrrc8a/ Volume-regulated anion channel subunit LRRC8A ELISA Kit

货号:

E4624r

商标:
EIAab®
监管等级:
别名:

Leucine-rich repeat-containing protein 8A, Lrrc8

检测方法:
ELISA
特异性:
Natural and recombinant rat Volume-regulated anion channel subunit LRRC8A
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Rat Lrrc8a ELISA Kit
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Rat Lrrc8a ELISA Kit
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通用注释


亚单元:
Heterooligomer; heterooligomerizes with other LRRC8 proteins (LRRC8B, LRRC8C, LRRC8D and/or LRRC8E), possibly to form a heterohexamer. In vivo, the subunit composition may depend primarily on expression levels, and heterooligomeric channels containing various proportions of the different LRRC8 proteins may coexist.


功能:
Essential component of the volume-regulated anion channel (VRAC, also named VSOAC channel), an anion channel required to maintain a constant cell volume in response to extracellular or intracellular osmotic changes. The VRAC channel conducts iodide better than chloride and may also conduct organic osmolytes like taurine. Required for channel activity, together with at least one other family member (LRRC8B, LRRC8C, LRRC8D or LRRC8E); channel characteristics depend on the precise subunit composition. Can form functional channels by itself (in vitro). Involved in B-cell development: required for the pro-B cell to pre-B cell transition (By similarity). Also required for T-cell development.


亚细胞位置:
Cell membrane Multi-pass membrane protein The leucine-rich repeat (LRR) domain is on the cytoplasmic side of the cell membrane.


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