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LAMTOR2 (基因名), Ragulator complex protein LAMTOR2 (蛋白名), ltor2_bovin.
产品名称:

Bovine LAMTOR2/ Ragulator complex protein LAMTOR2 ELISA Kit

货号:

E3896b

商标:
EIAab®
监管等级:
别名:

Late endosomal/lysosomal adaptor and MAPK and MTOR activator 2

检测方法:
ELISA
特异性:
Natural and recombinant bovine Ragulator complex protein LAMTOR2
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Bovine LAMTOR2 ELISA Kit
规格 & 价格: cart
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Bovine LAMTOR2 ELISA Kit
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通用注释


亚单元:
Part of the Ragulator complex composed of LAMTOR1, LAMTOR2, LAMTOR3, LAMTOR4 and LAMTOR5. LAMTOR4 and LAMTOR5 form a heterodimer that interacts, through LAMTOR1, with a LAMTOR2, LAMTOR3 heterodimer. The Ragulator complex interacts with both the mTORC1 complex and heterodimers constituted of the Rag GTPases RRAGA, RRAGB, RRAGC and RRAGD; regulated by amino acid availability. The Ragulator complex interacts with SLC38A9; the probable amino acid sensor (By similarity). Interacts with LAMTOR1 and LAMTOR3; the interaction is direct. Interacts with MAPK1 and MAP2K1.


功能:
As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.


亚细胞位置:
Late endosome membrane Peripheral membrane protein Cytoplasmic side Lysosome membrane Peripheral membrane protein Cytoplasmic side


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