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Npc1l1 (基因名), NPC1-like intracellular cholesterol transporter 1 (蛋白名), npcl1_rat.
产品名称:

Rat Npc1l1/ NPC1-like intracellular cholesterol transporter 1 ELISA Kit

货号:

E5656r

商标:
EIAab®
监管等级:
别名:

Niemann-Pick C1-like protein 1

检测方法:
ELISA
特异性:
Natural and recombinant rat NPC1-like intracellular cholesterol transporter 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cardiovascular
Rat Npc1l1 ELISA Kit
规格 & 价格: cart
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Rat Npc1l1 ELISA Kit
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通用注释


亚单元:
Interacts with RAB11A, MYO5B and RAB11FIP2. Interaction with RAB11A, MYO5B and RAB11FIP2 is required for proper transport to the plasma membrane upon cholesterol depletion (By similarity). Interacts with NPC2 (By similarity). Interactss with LIMA1 (By similarity).


功能:
Plays a major role in cholesterol homeostasis. Is critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte. Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption (By similarity). Lack of activity leads to multiple lipid transport defects. The protein may have a function in the transport of multiple lipids and their homeostasis. Acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation (By similarity).


亚细胞位置:
Apical cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein Subfractionation of brush border membranes from proximal enterocytes suggests considerable association with the apical membrane fraction. Exists as a predominantly cell surface membrane expressed protein.


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