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KIAA0578 (基因名), Neurexin-1 (蛋白名), nrx1a_rat.
产品名称:

Rat KIAA0578/ Neurexin-1 ELISA Kit

货号:

E15156r

商标:
EIAab®
监管等级:
别名:

Neurexin I-alpha, Neurexin-1-alpha, Nrxn1

检测方法:
ELISA
实验类型:
Sandwich
特异性:
Natural and recombinant rat Neurexin-1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
-
Rat KIAA0578 ELISA Kit
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Rat KIAA0578 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


精密度
批内差:已知浓度的3个样本在一个板子内重复检测20次,以评估批内精密度。
批内 CV: ≤4.2%
批间差:已知浓度的3个样本在不同的板子上重复测定5次,以评估测定批间精密度。
批间 CV: ≤7.0%
回收率
回收率:低、中和高浓度的分析物被掺入到血清或者血浆样本中,进行回收实验测定。

Sample Type

Average(%)

Recovery Range(%)

Serum

103

97-109

Plasma

105

99-111

 

 

 

 

线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

109-118%

107-117%

93-104%

81-94%

EDTA plasma(n=5)

102-113%

94-103%

112-122%

107-117%

heparin plasma(n=5)

82-91%

 

104-116%

100-109%

90-100%

 

通用注释


亚单元:
Interacts with SYT13 and SYTL1 (By similarity). Interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN1 forming a heterotetramer, where one NLGN1 dimer interacts with one NRXN1 dimer. Interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN1, NLGN2 and NLGN3; these interactions are calcium-dependent. Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity). Interacts (via laminin G-like domain 2 and/or laminin G-like domain 6) with NLGN4. Interacts (via laminin G-like domain 2) with NXPH1 and NXPH3. Alpha-type isoforms (neurexin-1-alpha) interact (via laminin G-like domain 2 and/or laminin G-like domain 6) with DAG1 (via alpha-dystroglycan chain). Alpha-type isoforms interact with alpha-latrotoxin from spider venom. The cytoplasmic C-terminal region binds to CASK, CASKIN1 and APBA1. Isoform 9a and isoform 13a bind to DAG1 (via alpha-dystroglycan chain). Isoform 13a binds to alpha-latrotoxin. Interacts with LRRTM1, LRRTM2, LRRTM3 and LRRTM4.


功能:
Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels (By similarity). Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their interactions (via the extracellular domains) with neuroligin family members, CBLN1 or CBLN2. In vitro, triggers the de novo formation of presynaptic structures. May be involved in specification of excitatory synapses. Alpha-type isoforms were first identified as receptors for alpha-latrotoxin from spider venom.


亚细胞位置:
Cell membrane Single-pass type I membrane protein Cell junction Synapse Presynaptic cell membrane


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