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OAZ1 (基因名), Ornithine decarboxylase antizyme 1 (蛋白名), oaz1_bovin.
产品名称:

Bovine OAZ1/ Ornithine decarboxylase antizyme 1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

ODC-Az

检测方法:
ELISA
特异性:
Natural and recombinant bovine Ornithine decarboxylase antizyme 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cell Biology
Bovine OAZ1 ELISA Kit
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Bovine OAZ1 ELISA Kit
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通用注释


亚单元:
Interacts with ODC1 and thereby sterically blocks ODC homodimerization. Forms a ternary complex with PSMB4 and OAZ1 before PSMB4 is incorporated into the 20S proteasome. Interacts with AZIN2; this interaction disrupts the interaction between the antizyme and ODC1.


功能:
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. Triggers ODC degradation by inducing the exposure of a cryptic proteasome-interacting surface of ODC. Stabilizes AZIN2 by interfering with its ubiquitination. Also inhibits cellular uptake of polyamines by inactivating the polyamine uptake transporter. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. Involved in the translocation of AZIN2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol.


亚细胞位置:
N/A


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