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OAZ3 (基因名), Ornithine decarboxylase antizyme 3 (蛋白名), oaz3_human.
产品名称:

Human OAZ3/ Ornithine decarboxylase antizyme 3 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

AZ3

检测方法:
ELISA
特异性:
Natural and recombinant human Ornithine decarboxylase antizyme 3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human OAZ3 ELISA Kit
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Human OAZ3 ELISA Kit
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通用注释


亚单元:
Interacts with ODC1 and thereby sterically blocks ODC homodimerization (By similarity). Interacts with AZIN2; this interaction disrupts the interaction between the antizyme and ODC1 (PubMed:17900240). Interacts with GGN.


功能:
Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis and uptake in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimers. Does not target the ODC monomers for degradation, which allows a protein synthesis-independent restoration of ODC activity (PubMed:17900240). Stabilizes AZIN2 by interfering with its ubiquitination. Involved in the translocation of AZNI2 from ER-Golgi intermediate compartment (ERGIC) to the cytosol. Probably plays a key role in spermatogenesis by regulating the intracellular concentration of polyamines in haploid germ cells.


亚细胞位置:
Nucleus Cytoplasm


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