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OBSCN (基因名), Obscurin (蛋白名), obscn_human.
产品名称:

Human OBSCN/ Obscurin ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

Obscurin-RhoGEF, Obscurin-myosin light chain kinase, Obscurin-MLCK, KIAA1556, KIAA1639

检测方法:
ELISA
特异性:
Natural and recombinant human Obscurin
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Human OBSCN ELISA Kit
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Human OBSCN ELISA Kit
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通用注释


亚单元:
Interacts (via protein kinase domain 2) with CDH2 and (via protein kinase domain 1) with ATP1B1 (By similarity). Isoform 3 interacts with TTN/titin and calmodulin (PubMed:11448995, PubMed:11717165). Isoform 3 interacts with ANK1 isoform Mu17/ank1.5 (PubMed:12527750).


功能:
Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1.


亚细胞位置:
Cytoplasm Myofibril Sarcomere M line Cytoplasm Myofibril Sarcomere Z line Cell membrane Sarcolemma Nucleus Colocalizes with CDH2 and ATP1B1 to the sarcolemma and to intercalating disks in cardiac muscles. Colocalizes with ATP1B1 to M line and Z line in cardiac muscles.


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