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PACSIN1 (基因名), Protein kinase C and casein kinase substrate in neurons protein 1 (蛋白名), pacn1_bovin.
产品名称:

Bovine PACSIN1/ Protein kinase C and casein kinase substrate in neurons protein 1 ELISA Kit

货号:

E15722b

商标:
EIAab®
监管等级:
检测方法:
ELISA
特异性:
Natural and recombinant bovine Protein kinase C and casein kinase substrate in neurons protein 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Bovine PACSIN1 ELISA Kit
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Bovine PACSIN1 ELISA Kit
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通用注释


亚单元:
Homodimer. May form heterooligomers with other PACSINs. Interacts with MAPT (By similarity). Interacts (via SH3 domain) with SYNJ1 and WASL. Interacts (via SH3 domain) with DNM1; the interaction is reduced by DNM1 phosphorylation. Interacts with DNM2 and DNM3. Interacts with both COBL and DBNL. Identified in a complex composed of COBL, PACSIN1 and WASL. Interacts with EHD1 and EHD3. Interacts with TRPV4.


功能:
Binds to membranes via its F-BAR domain and mediates membrane tubulation. Plays a role in the reorganization of the microtubule cytoskeleton via its interaction with MAPT; this decreases microtubule stability and inhibits MAPT-induced microtubule polymerization. Plays a role in cellular transport processes by recruiting DNM1, DNM2 and DNM3 to membranes. Plays a role in the reorganization of the actin cytoskeleton and in neuron morphogenesis via its interaction with COBL and WASL, and by recruiting COBL to the cell cortex. Plays a role in the regulation of neurite formation, neurite branching and the regulation of neurite length. Required for normal synaptic vesicle endocytosis; this process retrieves previously released neurotransmitters to accommodate multiple cycles of neurotransmission. Required for normal excitatory and inhibitory synaptic transmission.


亚细胞位置:
Cytoplasm Cell projection Cell junction Synapse Synaptosome Cell projection Ruffle membrane Membrane Peripheral membrane protein Cytoplasmic vesicle membrane Peripheral membrane protein Cell junction Synapse Cytoplasm Cytosol Cell membrane Peripheral membrane protein Cytoplasmic side Colocalizes with MAPT in axons. In primary neuronal cultures, present at a high level in presynaptic nerve terminals and in the cell body. Colocalizes with DNM1 at vesicular structures in the cell body and neurites. Associates with membranes via its F-BAR domain (By similarity).


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