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Ripk3 (基因名), Receptor-interacting serine/threonine-protein kinase 3 (蛋白名), ripk3_rat.
产品名称:

Rat Ripk3/ Receptor-interacting serine/threonine-protein kinase 3 ELISA Kit
受体相互作用的丝氨酸/苏氨酸蛋白激酶3

货号:

E11168r

商标:
EIAab®
监管等级:
别名:

Homocysteine respondent protein HCYP2, RIP-like protein kinase 3, Receptor-interacting protein 3, RIP-3, Rip3

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
0.156-10ng/mL
灵敏度:
0.088ng/mL
特异性:
Natural and recombinant rat Receptor-interacting serine/threonine-protein kinase 3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Immunology
Rat Ripk3 ELISA Kit
规格 & 价格: cart
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Rat Ripk3 ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


精密度
批内差:已知浓度的3个样本在一个板子内重复检测20次,以评估批内精密度。
批内 CV: ≤6.8%
批间差:已知浓度的3个样本在不同的板子上重复测定5次,以评估测定批间精密度。
批间 CV: ≤10.2%
回收率
回收率:低、中和高浓度的分析物被掺入到血清或者血浆样本中,进行回收实验测定。

Sample Type

Average(%)

Recovery Range(%)

Serum

98

92-104

Plasma

100

94-106

 

 

 

 

线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

98-109%

89-102%

98-107%

80-89%

EDTA plasma(n=5)

99-99%

99-108%

95-107%

83-93%

heparin plasma(n=5)

87-99%

 

114-124%

103-113%

80-89%

 

通用注释


亚单元:
Interacts (via RIP homotypic interaction motif) with RIPK1 (via RIP homotypic interaction motif); this interaction induces RIPK1 phosphorylation and formation of a RIPK1-RIPK3 necroptosis-inducing complex. Upon TNF-induced necrosis, the RIPK1-RIPK3 dimer further interacts with PGAM5 and MLKL; the formation of this complex leads to PGAM5 phosphorylation and increase in PGAM5 phosphatase activity (By similarity). Interacts with MLKL; the interaction is direct. Binds TRAF2 and is recruited to the TNFR-1 signaling complex. Interacts with PYGL, GLUL and GLUD1; these interactions result in activation of these metabolic enzymes (By similarity). Interacts with BIRC2/c-IAP1, BIRC3/c-IAP2 and XIAP/BIRC4. Interacts with ARHGEF2.


功能:
Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.


亚细胞位置:
Cytoplasm Cytosol Cell membrane Mitochondrion


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