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Rock1 (基因名), Rho-associated protein kinase 1 (蛋白名), rock1_rat.
产品名称:

Rat Rock1/ Rho-associated protein kinase 1 ELISA Kit
rho相关蛋白激酶

货号:

E15189r

商标:
EIAab®
监管等级:
别名:

Liver regeneration-related protein LRRG199, Rho-associated, coiled-coil-containing protein kinase 1, Rho-associated, coiled-coil-containing protein kinase I, p150 RhoA-binding kinase ROK beta, p160 ROCK-1, ROCK-I, p160ROCK, Ac2-154

检测方法:
ELISA
实验类型:
Sandwich
特异性:
Natural and recombinant rat Rho-associated protein kinase 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Cancer
Rat Rock1 ELISA Kit
规格 & 价格: cart
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Rat Rock1 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Homodimer (By similarity). Interacts with GEM, MYLC2B, RHOE, LIMK1, LIMK2, TSG101, CHORDC1, DAPK3, PFN1, PTEN and JIP3 (By similarity). Interacts with FHOD1 in a Src-dependent manner (By similarity). Interacts with ITGB1BP1 (via N-terminus and PTB domain) (By similarity). Interacts with RHOA (activated by GTP), RHOB, RHOC and PPP1R12A.


功能:
Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles. Promotes keratinocyte terminal differentiation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization.


亚细胞位置:
Cytoplasm Cytoplasm Cytoskeleton Microtubule organizing center Centrosome Centriole Golgi apparatus membrane Peripheral membrane protein Cell projection Bleb Cytoplasm Cytoskeleton Cell membrane Cell projection Lamellipodium Cell projection Ruffle Associated with the mother centriole and an intercentriolar linker. A small proportion is associated with Golgi membranes. Colocalizes with ITGB1BP1 and ITGB1 at the cell membrane predominantly in lamellipodia and membrane ruffles, but also in retraction fibers. Localizes at the cell membrane in an ITGB1BP1-dependent manner (By similarity).


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