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Septin7 (基因名), Septin-7 (蛋白名), sept7_rat.
产品名称:

Rat Septin7/ Septin-7 ELISA Kit

货号:

E16141r

商标:
EIAab®
监管等级:
别名:

CDC10 protein homolog, Cdc10, Sept7

检测方法:
ELISA
特异性:
Natural and recombinant rat Septin-7
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Cancer
Rat Septin7 ELISA Kit
规格 & 价格: cart
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Rat Septin7 ELISA Kit
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通用注释


亚单元:
Septins polymerize into heterooligomeric protein complexes that form filaments, and associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation. Filaments are assembled from asymmetrical heterotrimers, composed of SEPTIN2, SEPTIN6 and SEPTIN7 that associate head-to-head to form a hexameric unit. Within the trimer, directly interacts with SEPTIN6, while interaction with SEPTIN2 seems indirect. In the absence of SEPTIN6, forms homodimers. Interacts directly with CENPE and links CENPE to septin filaments composed of SEPTIN2, SEPTIN6 and SEPTIN7. Interacts with SEPTIN5. Component of a septin core octomeric complex consisting of SEPTIN12, SEPTIN7, SEPTIN6 and SEPTIN2 or SEPTIN4 in the order 12-7-6-2-2-6-7-12 or 12-7-6-4-4-6-7-12 and located in the sperm annulus; the SEPTIN12:SEPTIN7 association is mediated by the respective GTP-binding domains (By similarity). Interacts with SEPTIN2, SEPTIN7, SEPTIN8, SEPTIN9 and SEPTIN11 (PubMed:15485874).


功能:
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Required for normal progress through mitosis. Involved in cytokinesis. Required for normal association of CENPE with the kinetochore. Plays a role in ciliogenesis and collective cell movements. Forms a filamentous structure with SEPTIN12, SEPTIN6, SEPTIN2 and probably SEPTIN4 at the sperm annulus which is required for the structural integrity and motility of the sperm tail during postmeiotic differentiation (By similarity).


亚细胞位置:
Cytoplasm Chromosome Centromere Kinetochore Cytoplasm Cytoskeleton Spindle Cleavage furrow Midbody Cytoplasm Cytoskeleton Cilium axoneme Cell projection Cilium Flagellum Distributed throughout the cytoplasm in prometaphase cells. Associated with the spindle during metaphase. Associated with the central spindle and at the cleavage furrow in anaphase cells. Detected at the midbody in telophase (By similarity). Associated with actin stress fibers. According to PubMed:15485874, also found in the nucleus. Found in the sperm annulus (By similarity).


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