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SOCS3 (基因名), Suppressor of cytokine signaling 3 (蛋白名), socs3_chick.
产品名称:

Chicken SOCS3/ Suppressor of cytokine signaling 3 ELISA Kit
细胞因子信号转导抑制因子3

货号:

E1684c

商标:
EIAab®
监管等级:
别名:

SOCS-3

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
78-5000pg/mL
灵敏度:
33pg/mL
特异性:
Natural and recombinant chicken Suppressor of cytokine signaling 3
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Immunology
Chicken SOCS3 ELISA Kit
规格 & 价格: cart
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Chicken SOCS3 ELISA Kit
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产品说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


通用注释


亚单元:
Interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and EPO receptor. Binding to JAK is mediated through the KIR and SH2 domains to a phosphorylated tyrosine residue within the JAK JH1 domain. Binds specific activated tyrosine residues of the leptin, EPO and gp130 receptors.


功能:
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors (By similarity). Binding to JAK2 inhibits its kinase activity (By similarity). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Regulates IL-6 signaling in vivo. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize IL6ST.


亚细胞位置:
N/A


该产品尚未在任何出版物中被引用。
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