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MAPT (基因名), Microtubule-associated protein tau (蛋白名), tau_human.
产品名称:

Human MAPT/ Microtubule-associated protein tau ELISA Kit
微管结合蛋白T

货号:

E1983h

商标:
EIAab®
监管等级:
别名:

Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPTL, MTBT1, TAU

检测方法:
ELISA
实验类型:
Sandwich
检测范围:
7.8-500pg/mL
灵敏度:
3.5pg/mL
特异性:
Natural and recombinant human Microtubule-associated protein tau
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
实验步骤:
实验步骤
研究领域:
Neurosciences
Human MAPT ELISA Kit
规格 & 价格: cart
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Human MAPT ELISA Kit
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产品说明书
数据表: 下载说明书
说明书: 下载说明书
MSDS: MSDS
在线询价


精密度
批内差:已知浓度的3个样本在一个板子内重复检测20次,以评估批内精密度。
批内 CV: ≤6.7%
批间差:已知浓度的3个样本在不同的板子上重复测定5次,以评估测定批间精密度。
批间 CV: ≤10.3%
回收率
回收率:低、中和高浓度的分析物被掺入到血清或者血浆样本中,进行回收实验测定。

Sample Type

Average(%)

Recovery Range(%)

Serum

106

100-112

Plasma

108

102-114

 

 

 

 

线性
线性:给定样本通过梯度稀释,每次稀释的测量值与理论值的比值。

Sample

1:2

1:4

1:8

1:16

serum(n=5)

100-109%

95-106%

98-107%

89-101%

EDTA plasma(n=5)

91-101%

101-111%

95-105%

103-113%

heparin plasma(n=5)

89-98%

 

94-103%

99-110%

92-102%

 

通用注释


亚单元:
Interacts with PSMC2 through SQSTM1 (By similarity). Interacts with SQSTM1 when polyubiquitinated (PubMed:15953362). Interacts with FKBP4 (By similarity). Binds to CSNK1D (PubMed:14761950). Interacts with SGK1 (PubMed:16982696). Interacts with EPM2A; the interaction dephosphorylates MAPT at Ser-396 (PubMed:19542233).


功能:
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.


亚细胞位置:
Cytoplasm Cytosol Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm Cytoskeleton Cell projection Axon Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components.


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