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TMEM100 (基因名), Transmembrane protein 100 (蛋白名), tm100_bovin.
产品名称:

Bovine TMEM100/ Transmembrane protein 100 ELISA Kit

货号:

E16165b

商标:
EIAab®
监管等级:
检测方法:
ELISA
特异性:
Natural and recombinant bovine Transmembrane protein 100
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Bovine TMEM100 ELISA Kit
规格 & 价格: cart
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Bovine TMEM100 ELISA Kit
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通用注释


亚单元:
Interacts (via C-terminus) with TRPA1 and TRPV1.


功能:
Plays a role during embryonic arterial endothelium differentiation and vascular morphogenesis through the ACVRL1 receptor-dependent signaling pathway upon stimulation by bone morphogenetic proteins, such as GDF2/BMP9 and BMP10. Involved in the regulation of nociception, acting as a modulator of the interaction between TRPA1 and TRPV1, two molecular sensors and mediators of pain signals in dorsal root ganglia (DRG) neurons. Mechanistically, it weakens their interaction, thereby releasing the inhibition of TRPA1 by TRPV1 and increasing the single-channel open probability of the TRPA1-TRPV1 complex.


亚细胞位置:
Cell membrane Multi-pass membrane protein Membrane Multi-pass membrane protein Perikaryon Cytoplasm Perinuclear region Endoplasmic reticulum Colocalized with HSPA5 in the endoplasmic reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in neural cell bodies and neural fibers of the enteric nervous system (By similarity).


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