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UBE2V1 (基因名), Ubiquitin-conjugating enzyme E2 variant 1 (蛋白名), ub2v1_bovin.
产品名称:

Bovine UBE2V1/ Ubiquitin-conjugating enzyme E2 variant 1 ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

UEV-1

检测方法:
ELISA
特异性:
Natural and recombinant bovine Ubiquitin-conjugating enzyme E2 variant 1
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
Immunology
Bovine UBE2V1 ELISA Kit
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Bovine UBE2V1 ELISA Kit
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产品说明书
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通用注释


亚单元:
Heterodimer with UBE2N. Interacts (UBE2V2-UBE2N heterodimer) with the E3 ligase STUB1 (via the U-box domain); the complex has a specific 'Lys-63'-linked polyubiquitination activity. Interacts with TRAF6.


功能:
Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage (By similarity). Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes.


亚细胞位置:
Nucleus Excluded from the nucleolus.


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