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UBE2S (基因名), Ubiquitin-conjugating enzyme E2 S (蛋白名), ube2s_bovin.
产品名称:

Bovine UBE2S/ Ubiquitin-conjugating enzyme E2 S ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

E2 ubiquitin-conjugating enzyme S, Ubiquitin carrier protein S, Ubiquitin-protein ligase S

检测方法:
ELISA
特异性:
Natural and recombinant bovine Ubiquitin-conjugating enzyme E2 S
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Bovine UBE2S ELISA Kit
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Bovine UBE2S ELISA Kit
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产品说明书
在线询价


通用注释


亚单元:
Component of the APC/C complex. Interacts with CDC20, FZR1/CDH1 and VHL.


功能:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination.


亚细胞位置:
N/A


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