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UBE2W (基因名), Ubiquitin-conjugating enzyme E2 W (蛋白名), ube2w_bovin.
产品名称:

Bovine UBE2W/ Ubiquitin-conjugating enzyme E2 W ELISA Kit

货号:
-
商标:
EIAab®
监管等级:
别名:

E2 ubiquitin-conjugating enzyme W, N-terminal E2 ubiquitin-conjugating enzyme, N-terminus-conjugating E2, Ubiquitin carrier protein W, Ubiquitin-protein ligase W

检测方法:
ELISA
特异性:
Natural and recombinant bovine Ubiquitin-conjugating enzyme E2 W
样品类型:
Serum, plasma, tissue homogenates, cell culture supernates and other biological fluids
样品数据:
研究领域:
-
Bovine UBE2W ELISA Kit
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Bovine UBE2W ELISA Kit
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产品说明书
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通用注释


亚单元:
Homodimer. Interacts with FANCL. Interacts with STUB1/CHIP.


功能:
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes monoubiquitination. Involved in degradation of misfolded chaperone substrates by mediating monoubiquitination of STUB1/CHIP, leading to recruitment of ATXN3 to monoubiquitinated STUB1/CHIP, and restriction of the length of ubiquitin chain attached to STUB1/CHIP substrates by ATXN3. After UV irradiation, but not after mitomycin-C (MMC) treatment, acts as a specific E2 ubiquitin-conjugating enzyme for the Fanconi anemia complex by associating with E3 ubiquitin-protein ligase FANCL and catalyzing monoubiquitination of FANCD2, a key step in the DNA damage pathway. In vitro catalyzes 'Lys-11'-linked polyubiquitination. Transfers ubiquitin in complex with RING/U-box type E3s that do not have active site cysteine residues to form thioester bonds with ubiquitin, and preferentially ubiquitinates the N-terminus of substrates, such as ATXN3, STUB1 and SUMO2.


亚细胞位置:
Nucleus In the nucleus, colocalizes with FANCL.


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